| Saturday, May 10, 2008 |
| 11:30 a.m. |
Registration, Poster Set-up and Buffet Lunch |
|
| 12:35 p.m. |
Symposium Opening & Welcome
Robert W. Sobol, PhD
Conference co-Chair |
|
| 12:40 p.m. |
Introduction of Keynote Lecturer: Dr. Titia de Lange, PhD
Laura J. Niedernhofer, MD, PhD
Conference co-Chair |
|
| 12:45 - 1:45 p.m. |
Keynote Lecture
Titia de Lange, PhD
How telomeres protect chromosome ends |
|
| 1:45 - 2:00 p.m. |
Break |
|
| 2:00 - 3:15 p.m. |
ORAL SESSION I - HR and DNA Damage Signaling |
|
| 2:00 - 2:15 p.m. |
TRF2 is required for repair of non-telomeric DNA double-strand breaks by homologous recombination
Zhiyong Mao, Andrei Seluanov, Ying Jiang, and Vera Gorbunova |
|
| 2:15 - 2:30 p.m. |
Role of Snm1B in cellular responses to DNA damage
Jennifer Mason, Anandi Karumbati, Gerwin Westfield, and JoAnn Sekiguchi |
|
| 2:30 - 2:45 p.m. |
The DDB1-CUL4BDDB2 complex participates in NER as a separate E3 ubiquitin Ligase
Maria G. Kapetanaki, Jennifer Guerrero-Santoro, Ching L. Hsieh, Ilya Gorbachinsky, Arthur S. Levine, and Vesna Rapić-Otrin |
|
| 2:45 - 3:00 p.m. |
ATM Represses DNA End-Degradation in an ATP-Dependent Manner
Elias A. Rahal, Leigh A. Henricksen, Yuling Li, John J. Turchi, Katherine S. Pawelczak, and Kathleen Dixon |
|
| 3:00 - 3:15 p.m. |
ATR-dependent checkpoint promotes repair of UV-induced DNA damage via direct interaction and phosphorylation of nucleotide excision repair factor XPA
Steven Mike Shell, Marina Roginskaya, Zhengke Li, and Yue Zou |
|
| 3:15 - 3:45 p.m. |
Coffee Break |
|
| 3:45 - 5:00 p.m. |
ORAL SESSION II – Polymerases in DNA Repair |
|
| 3:45 - 4:00 p.m. |
Identity of leading and lagging strand polymerases in eukaryotes: Do we have the final answer?
Victoria Liston, Miriam Menezes and Youri I.Pavlov |
|
| 4:00 - 4:15 p.m. |
Human DNA polymerase N (POLN): residues important for its low fidelity and bypass activity
Kei-ichi Takata and Richard D. Wood |
|
| 4:15 - 4:30 p.m. |
Contribution of hPMS2 to Replication Fidelity Through Microsatellite Sequences
Sandeep N. Shah and Kristin A. Eckert |
|
| 4:30 - 4:45 p.m. |
Evidence that FEN1 Functions in Mitochondrial DNA Stability in Yeast and Mice
Lidza Kalifa, Shey-Shing Sheu, Elaine A. Sia |
|
| 5:00 - 6:30 p.m. |
Poster Session |
|
| 6:30 - 8:00 p.m. |
Dinner, music and refreshments |
|
| 8:00 - 10:30 p.m. |
Dessert and Poster Session |
|
| Sunday, May 11, 2008 |
|
| 7:30 - 8:20 a.m. |
Buffet Breakfast |
|
| 8:25 a.m. |
Opening Remarks |
|
| 8:30 - 10:00 a.m. |
ORAL SESSION III – Targeting DNA Repair pathways |
|
| 8:30 - 8:45 a.m. |
A small molecule induces MSH2-dependent cell death independent of DNA binding
F. Salsbury, J. Clodfelter, and K. D. Scarpinato |
|
| 8:45 - 9:00 a.m. |
Discovery of Tyrosyl-DNA Phosphodiesterase I (Tdp1) Inhibitors for Anticancer Therapy
Thomas S. Dexheimer, Smitha Antony, Christophe Marchand, Andrew G. Stephen, Iwona Weidlich, Marc Nicklaus, Robert J. Fisher, Vincent C. Njar, and Yves Pommier |
|
| 9:00 - 9:15 a.m. |
The Effect of Small Molecule Inhibitors of Replication Protein A on DNA binding, Cellular Function and Platinum Sensitivity
Shuck, SC, Short, EA, Montgomery, JS, Turchi, JJ |
|
| 9:15 - 9:30 a.m. |
The role of kinase and phosphatase activities of hPNK in response to DNA damage induced by different genotoxic agents
Nasser Tahbaz, Michael Weinfeld |
|
| 9:30 - 9:45 a.m. |
Irreversible chromosome damage accumulates rapidly in the absence of PIKK activity
Serah Choi, Jason S. White and Christopher J. Bakkenist |
|
| 9:45 - 10:00 a.m. |
UDG is a major DNA glycosylase having activity on F:T mispairs: Identifying a new target for fludarabine
Alina D. Bulgar, Lan Li, Yan Xu , Stanton L. Gerson and Lili Liu |
|
| 10:00 - 10:20 a.m. |
Coffee Break |
|
| 10:25 a.m. |
Introduction of Keynote lecturer: Dr. Keith Caldecott
Robert W. Sobol, PhD
Conference co-Chair |
|
| 10:30 - 11:30 a.m. |
Keynote Lecture
Keith Caldecott, PhD
Chromosomal single-strand breakage and genetic disease |
|
| 11:30 – 11:45 a.m. |
Break |
|
| 11:45 - 1:15 p.m. |
ORAL SESSION IV - Convergence of
DNA Repair Pathways
|
|
| 11:45 - 12:00 p.m. |
Base Excision Repair, Homologous Recombination and S-phase Checkpoint Signaling Processes Involved in the Cellular Response to Chemotherapeutic Inhibition of Thymidylate Synthase
Michael D. Wyatt, Alan S. Waldman, Zhengguan Yang, Barbara C. Waldman |
|
| 12:00 - 12:15 p.m |
The p38 Mitogen-Activated Protein Kinase Facilitates Nucleotide Excision Repair Through Mediating UV-induced DDB2 Degradation and Chromatin Relaxation
Qun Zhao, Bassant M.Barakat, Song Qin, Alo Ray, Mohamed A. El-Mahdy, Gulzar Wani, Qi-En Wang, and Altaf A. Wani |
|
| 12:15 - 12:30 p.m. |
High mobility group protein B1 enhances DNA repair and chromatin modification following DNA damage
Sabine S. Lange and Karen M. Vasquez |
|
| 12:30 - 12:45 p.m. |
PARP1 mediates acute cellular response to failed base excision repair
Jiangbo Tang, Xiaohong Wang, Ram N. Trivedi, Eva M. Goellner, Ashley R. Gaudi, Rachel Hardenstine and Robert W. Sobol |
|
| 12:45 - 1:00 p.m. |
Human Alkyladenine DNA Glycosylase (hAAG) Employs a Processive Search for DNA Damage
Mark Hedglin and Patrick O'Brien |
|
| 1:00 - 1:15 p.m. |
RNA microarray and histological analysis of ERCC1-deficient mouse brains indicates cerebellar neurodegeneration
Scott Carl Smith, Aruna Vashishta, Ph.D., Michal Hetman, M.D., Ph.D. |
|
| 1:15 - 1:45 p.m. |
Student Awards and Closing Statements
Robert Sobol, PhD
Conference co-Chair |
