11th Annual Midwest DNA Repair Symposium

BSRB Auditorium, University of Michigan, Ann Arbor, May 16-17, 2009

PROGRAM   For Abstract Book (pdf) please press HERE

Saturday, May 16

11:30     Registration, poster set-up, lunch

12:30     Welcome and opening of the symposium

               Mats Ljungman, University of Michigan

12:40     KEYNOTE LECTURE #1:

               Introduction by Mats Ljungman, University of Michigan

               “Transcription-coupled DNA repair:  two decades of progress

               and surprises”

               Philip C. Hanawalt, Stanford University

                    SESSION #1: Basic DNA Repair Processes

               Chair: Chris Canman, University of Michigan

1:30       “XPF-ERCC1 participates in the Fanconi anemia pathway of crosslink

               repair”

               Nikhil Bhagwat, University of Pittsburgh

1:45      “Roles of the MRN Complex in Class Switch Recombination”

                Elizabeth Spehalski, University of Michigan

2:00      “Human ortholog of the plant CTC1 (Conserved Telomere Capping 1)

                is the Pol-α Accessory Factor (AAF): knockdown phenotype and role

                in telomere replication”

                Dimitri Churikov, University of Cincinnati

2:15       “Purification and characterization of exo-nuclease free Artemis:

                 Implications for DNA-PK dependent processing of DNA termini in

                 NHEJ catalyzed DSB repair”

                 Katherine S. Pawelczak, Indiana University

2:30      “Crystal structure of RecE exonuclease reveals a toroidal tetramer for

                processing double stranded DNA breaks”

                Jinjin Zhang, Ohio State University

2:45       “TRF2 regulates WRN helicase/exonculease displacement of

                telomeric Holliday Junctions”

                Gerald Nora, University of Pittsburgh

3:00        Coffee break

               SESSION #2: DNA Damage Response

               Chair: Xiaochun Yu, University of Michigan

3:30       “PALB2 physically and functionally connects BRCA1 and BRCA2 into

                a pathway of homologous recombination”

                Paul Andreassen, University of Cincinnati

3:45       “Sequence specificity of DNA-cytosine deaminases required for

                antibody maturation and retrovirus restriction”

                Michael Carpenter, Wayne State University

4:00       “Dissection of Rad9 BRCT Domain Function In The Mitotic

                Checkpoint Response To Telomere Uncapping”

                Chinonye Nnakwe, University of Chicago

4:15       “ATM-mediated DNA damage signals enforce mono-allelic

                rearrangement during V(D)J recombination”

                Bu Yin, University of Pennsylvania

4:30       “SWI/SNF core component SNF5 facilitates NER by influencing H2AX

                phosphorylation and downstream checkpoint activation”

                Alo Ray, Ohio State University

4:45      “A tale of two tails: Activation of DNA damage checkpoint kinase

                Mec1/ATR by the 9-1-1 clamp and by Dpb11/TopBP1”

                Peter Burgers, Washington University

5:00        POSTER SESSION

7:00        Dinner in BSRB Atrium

8:30        KEYNOTE LECTURE #2:

                Introduction by Xiaochun Yu

                “DNA Damage Signaling and DNA Repair”

                Junjie Chen, Yale University

       

9:30-?     Guided tours to the Nightlife of Ann Arbor!

Sunday May 17

                SESSION #3: DNA Repair and cancer

                Chair: JoAnn Sekiguchi, University of Michigan

8:30       “Age Related Mismatch Repair Failure in Hematopoietic Stem Cells”

                Jonathan Kenyon, Case Western Reserve University

8:45      “ROC1/RBX1 E3 ubiquitin ligase silencing triggers DNA damage

                response and suppresses tumor cell growth via sequential induction

                of G2/M arrest, apoptosis, and senescence”

                Lijun Jia, University of Michigan

9:00       “A novel mechanism for Rad6 in breast cancer beyond postreplication

                DNA repair”

                Malathy Shekhar, Wayne State University

9:15       “Prolonged cell cycle response of HeLa cells to low-level alkylation

                exposure”

                Kandace Williams, University of Toledo

9:30       “Induction of mismatch repair-dependent cell death by small

                molecules”

                Aksana Vasilyeva, Wake Forest University

9:45       “Dual targeting of BER and NAD+ Biosynthesis enhances the

                sensitivity of glioblastoma cells to Temozolomide”

                Eva Goellner, University of Pittsburgh

10:00      Coffee break

                SESSION #4: Chromosome Instability

                Chair: Tom Glover, University of Michigan

10:30     “Replication stress induces genome wide copy number changes in

                human cells that involve non-homologous repair mechanisms”

                Martin Arlt, University of Michigan

10:45     “Loss of Bloom syndrome protein destabilizes human genomic

                architecture”

                Michael Killen, University of Kentucky

11:00    “Novel Mechanisms of Minisatellite DNA Repeat Tract Alteration in

                Quiescent Cells”

                Maire Kate Kelly, University of Minnesota

11:15     “Break-induced replication:  a source of genetic instability”

                Angela Deem, Indianapolis University-Purdue University Indianapolis

11:30      KEYNOTE LECTURE #3:

                Introduction by David Ferguson, University of Michigan

               “Rad50 and XPD ATPase machines and their disease-causing

                mutations: insights from genetics and structures combined”

                John Tainer, Scripps Research Institute

12:20     Student Awards, Closing of the Symposium

               Tom Wilson, University of Michigan

               Have a safe trip home!