Environmental agents contribute to the development and progression of human disease, including cancer, cardiovascular disease, diabetes and neurodegeneration. Identification of the environmental exposures that promote disease and the mechanism by which they do is essential for disease prevention and the identification of individuals at risk of disease.

Many environmental exposures induce DNA damage and failure to resolve these lesions through one or more DNA repair processes leads to genome instability and cancer or cytotoxicity and degenerative diseases.

Presentation of the latest discoveries in the field of DNA repair will provide a conceptual framework for rational diagnostic, prognostic and therapeutic strategies to prevent or treat a variety of human diseases. The Annual Midwest DNA Repair Symposium (AMDRS) provides a regular forum for deliberating a range of topics in basic and applied research on DNA repair and its relationship to human disease, with a special emphasis on promoting collaborations and engaging young scientists in environmental sciences.

The 10th Annual Midwest DNA Repair Symposium will bring together scientists from the U.S. Midwestern States to enhance collaborations and disseminate the current state of knowledge regarding the mechanisms of DNA repair pathways and their influence on environmentally induced DNA damage and human disease.